ABSTRACT
OBJECTIVE: Estimation of the specific thresholds of the Caprini risk score (CRS) that are associated with the increased incidence of venous thromboembolism (VTE) across different specialties, including identifying the highest level of risk. BACKGROUND: Accurate risk assessment remains an important but often challenging aspect of VTE prophylaxis. One well-established risk assessment model is CRS, which has been validated in thousands of patients from many different medical and surgical specialties. METHODS: A search of MEDLINE and the Cochrane Library was performed in March 2022. Manuscripts that reported on 1) patients admitted to medical or surgical departments and 2) had their VTE risk assessed by CRS and 3) reported on the correlation between the score and VTE incidence, were included in the analysis. RESULTS: A total of 4562 references were identified, and the full text of 202 papers was assessed for eligibility. The correlation between CRS and VTE incidence was reported in 68 studies that enrolled 4,207,895 patients. In all specialties, a significant increase in VTE incidence was observed in patients with a CRS of ≥5. In most specialties thresholds of ≥7, ≥9, and ≥11-12 were associated with dramatically increased incidences of VTE. In COVID-19, cancer, trauma, vascular, general, head and neck, and thoracic surgery patients with ≥9 and ≥11-12 scores the VTE incidence was extremely high (ranging from 13% to 47%). CONCLUSION: The Caprini score is being used increasingly to predict VTE in many medical and surgical specialties. In most cases the VTE risk for individual patients increases dramatically at a threshold CRS of 7-11.
ABSTRACT
COVID-19 has created an entirely new unknown environment with new risks. Various restrictive national measures seeking to protect health took precedence over economic measures. Moreover, a large number of businesses are entirely dependent on international trade and exports. The aim of this paper is to map and analyze the development of small and medium enterprises' exports during the COVID-19 pandemic in the Czech Republic. Moreover, it identifies the most significant export risks and their perception by small and medium enterprises. The chi-square test, Cramer's coefficient, and exact binomial test were used to verify the statistical dependencies of research questions and hypotheses. Empirically, the statistically significant impact of the COVID-19 pandemic on the decline in small and medium enterprises' exports was confirmed. In connection with the effectiveness of risk management, it was found that less than 50% of enterprises in the research sample are not ISO 31000-certified. The study concluded that the most significant export risks confirmed by statistical testing were COVID-19 risks and payment morale of foreign trading partners. © Romana Heinzova, Eva Hoke, Tomas Urbanek, Pavel Taraba, 2023.